Three of the teenage girls in the SUV died; the other was in critical condition at a hospital, officials said.
A woman in the car was killed and a pregnant woman in the back seat lost her unborn child from injuries in the crash just before midnight Friday, state Highway Patrol spokeswoman Laura McPherson said.
A man driving the car and a child passenger also were injured and taken to a hospital. McPherson said the woman killed was Jeweline Ledbetter King, 49.
The SUV lost control on a curve on a two-lane highway, flipped on its side and crossed the center lane, slamming into an oncoming Ford Taurus. The SUV erupted into flames.