There are no reports of injuries aboard the train.
Canton Township Police Sgt. Craig Wilsher says the crash occurred around 12:30 p.m. Thursday in the Wayne County community about 20 miles west of Detroit.
Wilsher says the vehicle was heading north when it crossed the train tracks and was hit, pushing the car about 150 feet from one road crossing to another. He wasn't sure of the victims' ages.
Amtrak spokesman Marc Magliari says the train was on its way from Detroit to Chicago. He says passengers will be taken by bus to Ann Arbor to board another train.
The National Transportation Safety Board didn't immediately have any information about the crash.