Los Angeles fire spokesman Brian Humphrey says the fire is moving toward the Getty Center and Mt. St. Mary's College, but both are "well-protected by a large number of firefighters."
Humphrey says the fire started at about 12:50 a.m. Thursday west of Interstate 405 and more than 300 firefighters helped by water-dropping aircraft are responding.
Humphrey says all lanes of the 405 Freeway have been closed through the Sepulveda Pass.
Authorities are telling residents in the Brentwood area they may need to evacuate.